[HTML][HTML] Unsaturated fatty acids down-regulate srebp isoforms 1a and 1c by two mechanisms in HEK-293 cells
VC Hannah, J Ou, A Luong, JL Goldstein… - Journal of Biological …, 2001 - ASBMB
Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription
factors that increase the synthesis of fatty acids as well as cholesterol in animal cells. All
three SREBP isoforms (SREBP-1a,-1c, and-2) are subject to feedback regulation by
cholesterol, which blocks their proteolytic release from membranes. Previous data indicate
that the SREBPs are also negatively regulated by unsaturated fatty acids, but the
mechanism is uncertain. In the current experiments, unsaturated fatty acids decreased the …
factors that increase the synthesis of fatty acids as well as cholesterol in animal cells. All
three SREBP isoforms (SREBP-1a,-1c, and-2) are subject to feedback regulation by
cholesterol, which blocks their proteolytic release from membranes. Previous data indicate
that the SREBPs are also negatively regulated by unsaturated fatty acids, but the
mechanism is uncertain. In the current experiments, unsaturated fatty acids decreased the …