Vitamin A and retinoic acid: induced fibroblast differentiation in vitro.
AA Demetriou, SM Levenson, G Rettura, E Seifter - Surgery, 1985 - europepmc.org
AA Demetriou, SM Levenson, G Rettura, E Seifter
Surgery, 1985•europepmc.orgThe role of vitamin A in wound healing and fibroplasia has been studied extensively in vivo
but the mechanism (s) of its action has not been established. In this study the effect of
vitamin A and retinoic acid on fibroblast growth and collagen accumulation in vitro was
examined. Vitamin A and retinoic acid added to Balb 3T3 mouse fibroblasts in tissue culture
resulted in induction of cell differentiation as manifested by a decrease in cell growth rate,
enhanced collagen accumulation, and morphologic differentiation. The results of this in vitro …
but the mechanism (s) of its action has not been established. In this study the effect of
vitamin A and retinoic acid on fibroblast growth and collagen accumulation in vitro was
examined. Vitamin A and retinoic acid added to Balb 3T3 mouse fibroblasts in tissue culture
resulted in induction of cell differentiation as manifested by a decrease in cell growth rate,
enhanced collagen accumulation, and morphologic differentiation. The results of this in vitro …
The role of vitamin A in wound healing and fibroplasia has been studied extensively in vivo but the mechanism (s) of its action has not been established. In this study the effect of vitamin A and retinoic acid on fibroblast growth and collagen accumulation in vitro was examined. Vitamin A and retinoic acid added to Balb 3T3 mouse fibroblasts in tissue culture resulted in induction of cell differentiation as manifested by a decrease in cell growth rate, enhanced collagen accumulation, and morphologic differentiation. The results of this in vitro study suggest that the stimulatory in vivo effect of vitamin A and retinoic acid on collagen accumulation and fibroplasia in healing wounds is due in a major way to fibroblast differentiation and enhanced collagen synthesis.
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