Chemokines: roles in leukocyte development, trafficking, and effector function
SJ Ono, T Nakamura, D Miyazaki, M Ohbayashi… - Journal of Allergy and …, 2003 - Elsevier
Chemokines, representing a large superfamily of 8-to 15-kd proteins, were originally
discovered through their ability to recruit various cell types into sites of inflammation. It is
now clear that these molecules play a much wider role in immune homeostasis, playing key
roles in driving the maturation, homing, and activation of leukocytes. In this review we
analyze the roles chemokines play in the development, recruitment, and activation of
leukocytes. Because signaling from the receptors drives these processes, signal …
discovered through their ability to recruit various cell types into sites of inflammation. It is
now clear that these molecules play a much wider role in immune homeostasis, playing key
roles in driving the maturation, homing, and activation of leukocytes. In this review we
analyze the roles chemokines play in the development, recruitment, and activation of
leukocytes. Because signaling from the receptors drives these processes, signal …