Polarized in vivo expression of IL-11 and IL-17 between acute and chronic skin lesions

M Toda, DYM Leung, S Molet, M Boguniewicz… - Journal of Allergy and …, 2003 - Elsevier
Background: In atopic dermatitis (AD) there is evidence of tissue fibrosis involving a number
of structural changes, including papillary dermal fibrosis and epidermal hyperplasia. These
changes are suggested to be the result of chronic inflammation of the skin. Several
remodeling-associated cytokines, including transforming growth factor (TGF) β1, IL-11, and
IL-17, have been shown to be increased in allergic diseases, including asthma. Objective:
We investigated TGF-β1, IL-11, and IL-17 expression in skin biopsy specimens recovered …