[HTML][HTML] Perlecan mediates the antiproliferative effect of Apolipoprotein E on smooth muscle cells: An underlying mechanism for the modulation of smooth muscle cell …
L Paka, IJ Goldberg, JC Obunike, SY Choi… - Journal of Biological …, 1999 - ASBMB
Apolipoprotein E (apoE) is known to inhibit cell proliferation; however, the mechanism of this
inhibition is not clear. We recently showed that apoE stimulates endothelial production of
heparan sulfate (HS) enriched in heparin-like sequences. Because heparin and HS are
potent inhibitors of smooth muscle cell (SMC) proliferation, in this study we determined apoE
effects on SMC HS production and cell growth. In confluent SMCs, apoE (10 μg/ml)
increased 35 SO 4 incorporation into PG in media by 25–30%. The increase in the medium …
inhibition is not clear. We recently showed that apoE stimulates endothelial production of
heparan sulfate (HS) enriched in heparin-like sequences. Because heparin and HS are
potent inhibitors of smooth muscle cell (SMC) proliferation, in this study we determined apoE
effects on SMC HS production and cell growth. In confluent SMCs, apoE (10 μg/ml)
increased 35 SO 4 incorporation into PG in media by 25–30%. The increase in the medium …