[HTML][HTML] Apolipoprotein E Receptor Binding VersusHeparan Sulfate Proteoglycan Binding in Its Regulation of Smooth Muscle Cell Migration and Proliferation
DK Swertfeger, DY Hui - Journal of Biological Chemistry, 2001 - ASBMB
This study showed that synthetic peptides containing either a single copy or tandem repeat
of the receptor binding domain sequence of apolipoprotein (apo) E, or a peptide containing
its C-terminal heparin binding domain, apoE-(211–243), were all effective inhibitors of
platelet-derived growth factor (PDGF)-stimulated smooth muscle cell proliferation. In
contrast, only the peptide containing a tandem repeating unit of the receptor binding domain
sequence of apoE, apoE-(141–155) 2, was capable of inhibiting PDGF-directed smooth …
of the receptor binding domain sequence of apolipoprotein (apo) E, or a peptide containing
its C-terminal heparin binding domain, apoE-(211–243), were all effective inhibitors of
platelet-derived growth factor (PDGF)-stimulated smooth muscle cell proliferation. In
contrast, only the peptide containing a tandem repeating unit of the receptor binding domain
sequence of apoE, apoE-(141–155) 2, was capable of inhibiting PDGF-directed smooth …