γ-Glutamyltranspeptidase–Deficient Knockout Mice as a Model to Study the Relationship Between Glutathione Status, Mitochondrial Function, and Cellular Function
Y Will, KA Fischer, RA Horton, RS Kaetzel, MK Brown… - Hepatology, 2000 - Elsevier
γ-Glutamyltranspeptidase (GGT)-deficient mice (GGT−/−) display chronic glutathione (GSH)
deficiency, growth retardation, and die at a young age (< 20 weeks). Using livers from these
mice, we investigated the relationship between GSH content, especially mitochondrial, and
mitochondrial and cellular function. We found that the GSH content of isolated liver
mitochondria was diminished by≥ 50% in GGT−/− mice when compared with wild-type
mice. Respiratory control ratios (RCRs) of GGT−/− mice liver mitochondria were≤ 60 …
deficiency, growth retardation, and die at a young age (< 20 weeks). Using livers from these
mice, we investigated the relationship between GSH content, especially mitochondrial, and
mitochondrial and cellular function. We found that the GSH content of isolated liver
mitochondria was diminished by≥ 50% in GGT−/− mice when compared with wild-type
mice. Respiratory control ratios (RCRs) of GGT−/− mice liver mitochondria were≤ 60 …