[HTML][HTML] Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate (S1P) receptors, S1P2/LPB2/EDG-5 and S1P3/LPB3 …

I Ishii, X Ye, B Friedman, S Kawamura… - Journal of Biological …, 2002 - ASBMB
Five cognate G protein-coupled receptors (S1P 1–5) have been shown to mediate various
cellular effects of sphingosine 1-phosphate (S1P). Here we report the generation of mice
null for S1P 2 and for both S1P 2 and S1P 3. S1P 2-null mice were viable and fertile and
developed normally. The litter sizes from S1P 2 S1P 3 double-null crosses were remarkably
reduced compared with controls, and double-null pups often did not survive through infancy,
although double-null survivors lacked any obvious phenotype. Mouse embryonic fibroblasts …