Stimulation of arterial endothelial cell prostacyclin synthesis by high density lipoproteins.
LN Fleisher, AR Tall, LD Witte, RW Miller… - Journal of Biological …, 1982 - ASBMB
Prostacyclin (PGI2) is a vasoactive prostaglandin synthesized by vascular endothelial and
smooth muscle cells. In order to investigate whether plasma lipoproteins influence the
biosynthesis and release of prostacyclin by vascular tissues, human high density
lipoproteins (HDL) and low density lipoproteins (LDL) were incubated with porcine arterial
endothelial cells grown in tissue culture. PGI2 production was measured by
radioimmunoassay of its stable metabolite, 6-keto-PGF1 alpha. In incubations of HDL with …
smooth muscle cells. In order to investigate whether plasma lipoproteins influence the
biosynthesis and release of prostacyclin by vascular tissues, human high density
lipoproteins (HDL) and low density lipoproteins (LDL) were incubated with porcine arterial
endothelial cells grown in tissue culture. PGI2 production was measured by
radioimmunoassay of its stable metabolite, 6-keto-PGF1 alpha. In incubations of HDL with …