[HTML][HTML] Sphingosine 1-phosphate activates Akt, nitric oxide production, and chemotaxis through a Giprotein/phosphoinositide 3-kinase pathway in endothelial cells

M Morales-Ruiz, MJ Lee, S Zöllner, JP Gratton… - Journal of Biological …, 2001 - ASBMB
Sphingosine 1-phosphate (SPP) binds to members of the endothelial differentiation gene
family (EDG) of receptors and leads to diverse signaling events including cell survival,
growth, migration and differentiation. However, the mechanisms of how SPP activates these
proangiogenic pathways are poorly understood. Here we show that SPP signals through the
EDG-1 receptor to the heterotrimeric G protein G i, leading to activation of the
serine/threonine kinase Akt and phosphorylation of the Akt substrate, endothelial nitric-oxide …