[HTML][HTML] Isoprenylcysteine carboxyl methyltransferase deficiency in mice

MO Bergo, GK Leung, P Ambroziak, JC Otto… - Journal of Biological …, 2001 - ASBMB
After isoprenylation, Ras and other CAAX proteins undergo endoproteolytic processing by
Rce1 and methylation of the isoprenylcysteine by Icmt (isoprenylcysteine carboxyl
methyltransferase). We reported previously thatRce1-deficient mice died during late
gestation or soon after birth. We hypothesized that Icmt deficiency might cause a milder
phenotype, in part because of reports suggesting the existence of more than one activity for
methylating isoprenylated proteins. To address this hypothesis and also to address the issue …