African trypanosomiasis and drug-induced encephalopathy: risk factors and pathogenesis
J Pepin, F Milord - Transactions of the Royal Society of Tropical Medicine …, 1991 - Elsevier
Data on 598 patients with Trypanosoma brucei gambiense sleeping sickness, with abnormal
cerebrospinal fluid (CSF) and treated with melarsoprol, were reviewed to determine risk
factors for drug-induced encephalopathy. The incidence of melarsoprol-induced
encephalopathy was increased in patients with trypanosomes present in the CSF, in patients
with a high CSF lymphocyte count, and among patients in whom no trypanosomes were
found in either the blood or the lymph node aspirate. Among patients with trypanosomes in …
cerebrospinal fluid (CSF) and treated with melarsoprol, were reviewed to determine risk
factors for drug-induced encephalopathy. The incidence of melarsoprol-induced
encephalopathy was increased in patients with trypanosomes present in the CSF, in patients
with a high CSF lymphocyte count, and among patients in whom no trypanosomes were
found in either the blood or the lymph node aspirate. Among patients with trypanosomes in …