Damage to the nervous system occurs in both African and American trypanosomiases, but it
differs considerably in form and extent in each disease, and with different strains and
disease stages. With Trypanosoma brucei infections there is a progressive central nervous
system (CNS) pathology which involves the meninges, choroid, blood-brain barrier, and
immunopathological changes including perivascular infiltrations, astrocyte activation and
alterations in the cytokine/mediator network. These changes underly the altered behaviour …