Nuclear lamins are intermediate filament-type proteins that are the major building blocks of
the nuclear lamina, a fibrous proteinaceous meshwork underlying the inner nuclear
membrane. Lamins can also be localized in the nuclear interior, in a diffuse or spotted
pattern. Nuclei assembledin vitroin the absence of lamins are fragile, indicating that lamins
mechanically stabilize the cell nucleus. Available evidence also indicates a role for lamins in
DNA replication, chromatin organization, spatial arrangement of nuclear pore complexes …