[HTML][HTML] Distinct mechanism of Helicobacter pylori-mediated NF-κB activation between gastric cancer cells and monocytic cells
S Maeda, M Akanuma, Y Mitsuno, Y Hirata… - Journal of Biological …, 2001 - ASBMB
NF-κB is a critical regulator of genes involved in inflammation. Gastric epithelial cells and
macrophages are considered the main sources of pro-inflammatory cytokines. We
investigated NF-κB activation by Helicobacter pylori in MKN45 gastric epithelial cells and
THP-1 monocytic cells. Although, cag pathogenicity island (PAI)-positiveH. pylori (wild type)
activated NF-κB in both cells, isogenic mutant of cagE (ΔcagE) activated it only in THP-1
cells. Supernatant from the wild type culture could activate NF-κB in THP-1 cells but not in …
macrophages are considered the main sources of pro-inflammatory cytokines. We
investigated NF-κB activation by Helicobacter pylori in MKN45 gastric epithelial cells and
THP-1 monocytic cells. Although, cag pathogenicity island (PAI)-positiveH. pylori (wild type)
activated NF-κB in both cells, isogenic mutant of cagE (ΔcagE) activated it only in THP-1
cells. Supernatant from the wild type culture could activate NF-κB in THP-1 cells but not in …