Natural Diversity in the N Terminus of the Mature Vacuolating Cytotoxin of Helicobacter pylori Determines Cytotoxin Activity
DP Letley, JC Atherton - Journal of bacteriology, 2000 - Am Soc Microbiol
DP Letley, JC Atherton
Journal of bacteriology, 2000•Am Soc MicrobiolNaturally occurring noncytotoxic vacA type s2 strains of Helicobacter pylori have a 12-
residue extension to the vacuolating cytotoxin (VacA) compared with cytotoxic type s1
strains. We show that adding the region encoding this extension to type s1 vacA completely
abolishes vacuolating cytotoxin activity but has no effect on VacA production.
residue extension to the vacuolating cytotoxin (VacA) compared with cytotoxic type s1
strains. We show that adding the region encoding this extension to type s1 vacA completely
abolishes vacuolating cytotoxin activity but has no effect on VacA production.
Abstract
Naturally occurring noncytotoxic vacA type s2 strains of Helicobacter pylori have a 12-residue extension to the vacuolating cytotoxin (VacA) compared with cytotoxic type s1 strains. We show that adding the region encoding this extension to type s1vacA completely abolishes vacuolating cytotoxin activity but has no effect on VacA production.
American Society for Microbiology