Blockade of CD40–CD40 ligand interactions protects against radiation-induced pulmonary inflammation and fibrosis
A Adawi, Y Zhang, R Baggs, P Rubin, J Williams… - Clinical immunology and …, 1998 - Elsevier
This study investigated whether CD40–CD40 ligand (L) interactions are important in
mediating ionizing radiation-induced lung toxicity. Radiotherapy is a key component in the
management of malignant diseases and is a conditioning regimen for bone marrow
transplantation. Unfortunately, radiation therapy is particularly toxic to the lung, potentially
inducing a fatal pneumonitis and fibrosis, thus limiting its effectiveness. There are no
therapies that protect against the development of radiation-induced lung toxicity. Using a …
mediating ionizing radiation-induced lung toxicity. Radiotherapy is a key component in the
management of malignant diseases and is a conditioning regimen for bone marrow
transplantation. Unfortunately, radiation therapy is particularly toxic to the lung, potentially
inducing a fatal pneumonitis and fibrosis, thus limiting its effectiveness. There are no
therapies that protect against the development of radiation-induced lung toxicity. Using a …