[HTML][HTML] Genetic regulation of primitive hematopoietic stem cell senescence
J Chen, CM Astle, DE Harrison - Experimental Hematology, 2000 - Elsevier
OBJECTIVE: To define effects of strain on PHSC (primitive hematopoietic stem cells)
senescence (decline in function with age) in vivo, and to map a locus that regulates PHSC
senescence. MATERIALS AND METHODS: Long-term function and self-renewal were
compared in bone marrow cells (BMC) from old and young mice of three strains: BALB/cBy
(BALB), DBA/2 (D2) and C57BL/6 (B6), using competitive repopulation and serial
transplantation in vivo. BMC from each old or young donor were mixed with standard doses …
senescence (decline in function with age) in vivo, and to map a locus that regulates PHSC
senescence. MATERIALS AND METHODS: Long-term function and self-renewal were
compared in bone marrow cells (BMC) from old and young mice of three strains: BALB/cBy
(BALB), DBA/2 (D2) and C57BL/6 (B6), using competitive repopulation and serial
transplantation in vivo. BMC from each old or young donor were mixed with standard doses …