If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells
IB Roninson, EV Broude, BD Chang - Drug Resistance Updates, 2001 - Elsevier
Inhibition of the program of apoptosis has been reported to have little or no effect on
clonogenic survival after treatment with drugs or radiation in several tumor cell lines. A
decrease in apoptosis is compensated in such cell lines by an increase in the fractions of
cells that undergo permanent growth arrest with phenotypic features of cell senescence, or
die through the process of mitotic catastrophe. Most of the tested tumor cell lines have
retained the capacity of normal cells to undergo accelerated senescence after treatment with …
clonogenic survival after treatment with drugs or radiation in several tumor cell lines. A
decrease in apoptosis is compensated in such cell lines by an increase in the fractions of
cells that undergo permanent growth arrest with phenotypic features of cell senescence, or
die through the process of mitotic catastrophe. Most of the tested tumor cell lines have
retained the capacity of normal cells to undergo accelerated senescence after treatment with …