[HTML][HTML] Growth hormone, interferon-γ, and leukemia inhibitory factor utilize insulin receptor substrate-2 in intracellular signaling
LS Argetsinger, G Norstedt, N Billestrup… - Journal of Biological …, 1996 - ASBMB
In this report, we demonstrate that insulin receptor substrate-2 (IRS-2) is tyrosyl-
phosphorylated following stimulation of 3T3-F442A fibroblasts with growth hormone (GH),
leukemia inhibitory factor and interferon-γ. In response to GH and leukemia inhibitory factor,
IRS-2 is immediately phosphorylated, with maximal phosphorylation detected at 15 min; the
signal is substantially diminished by 60 min. In response to interferon-γ, tyrosine
phosphorylation of IRS-2 was prolonged, with substantial signal still detected at 60 min …
phosphorylated following stimulation of 3T3-F442A fibroblasts with growth hormone (GH),
leukemia inhibitory factor and interferon-γ. In response to GH and leukemia inhibitory factor,
IRS-2 is immediately phosphorylated, with maximal phosphorylation detected at 15 min; the
signal is substantially diminished by 60 min. In response to interferon-γ, tyrosine
phosphorylation of IRS-2 was prolonged, with substantial signal still detected at 60 min …