[HTML][HTML] Growth Hormone, Interferon-γ, and Leukemia Inhibitory Factor Promoted Tyrosyl Phosphorylation of Insulin Receptor Substrate-1∗
LS Argetsinger, GW Hsu, MG Myers, N Billestrup… - Journal of Biological …, 1995 - ASBMB
The identification of JAK2 as a growth hormone (GH) receptor-associated, GH-activated
tyrosine kinase has established tyrosyl phosphorylation as a signaling mechanism for GH. In
the present study, GH is shown to stimulate tyrosyl phosphorylation of insulin receptor
substrate 1 (IRS-1), the principle substrate of the insulin receptor. Tyrosyl phosphorylation of
IRS-1 is a critical step in insulin signaling and provides binding sites for proteins with the
appropriate Src homology 2 domains, including the 85-kDa regulatory subunit of …
tyrosine kinase has established tyrosyl phosphorylation as a signaling mechanism for GH. In
the present study, GH is shown to stimulate tyrosyl phosphorylation of insulin receptor
substrate 1 (IRS-1), the principle substrate of the insulin receptor. Tyrosyl phosphorylation of
IRS-1 is a critical step in insulin signaling and provides binding sites for proteins with the
appropriate Src homology 2 domains, including the 85-kDa regulatory subunit of …