Growth hormone receptor antagonist improves insulin resistance in acromegaly
DR Rose, DR Clemmons - Growth hormone & IGF research, 2002 - Elsevier
Growth hormone hypersecretion is a known cause of insulin resistance. This change in
insulin sensitivity is believed to be mediated directly by growth hormone binding to its
receptor. Five subjects ages 28–55 years who were participating in a clinical study that had
been designed to assess the effects of a growth hormone receptor antagonist (Pegvisomant)
on disease activity in acromegaly were evaluated to determine the role of growth hormone
hypersecretion in inducing changes in insulin sensitivity. These subjects were treated with …
insulin sensitivity is believed to be mediated directly by growth hormone binding to its
receptor. Five subjects ages 28–55 years who were participating in a clinical study that had
been designed to assess the effects of a growth hormone receptor antagonist (Pegvisomant)
on disease activity in acromegaly were evaluated to determine the role of growth hormone
hypersecretion in inducing changes in insulin sensitivity. These subjects were treated with …