Modulation of insulin secretion by leptin
RB Ceddia, WN William Jr, AR Carpinelli… - … : The Vascular System, 1999 - Elsevier
The present study examines the acute effect of leptin (50 nM) on insulin secretion and on the
fractional outflow rates of 45Ca2+ and 86Rb+ from pancreatic islets isolated from male lean
albino rats. Under a constant physiological glucose concentration (5.6 mM), the addition of
leptin to the perifusion medium led to an increment in 45Ca2+ fractional outflow rate
followed by a significant (p< 0.05) increase (26%) in the insulin release. At low glucose
concentration (2.8 mM), leptin also elicited a significant (p< 0.05; 50–60%) increase in …
fractional outflow rates of 45Ca2+ and 86Rb+ from pancreatic islets isolated from male lean
albino rats. Under a constant physiological glucose concentration (5.6 mM), the addition of
leptin to the perifusion medium led to an increment in 45Ca2+ fractional outflow rate
followed by a significant (p< 0.05) increase (26%) in the insulin release. At low glucose
concentration (2.8 mM), leptin also elicited a significant (p< 0.05; 50–60%) increase in …