[HTML][HTML] Opposite effects of background genotype on muscle and liver insulin sensitivity of lipoatrophic mice: role of triglyceride clearance
C Colombo, M Haluzik, JJ Cutson, KR Dietz… - Journal of Biological …, 2003 - ASBMB
The metabolic phenotype of the A-ZIP/F-1 (AZIP) lipoatrophic mouse is different depending
on its genetic background. On both the FVB/N (FVB) and C57BL/6J (B6) backgrounds, AZIP
mice have a similarly severe lack of white adipose tissue and comparably increased insulin
levels and triglyceride secretion rates. However, on the B6 background, the AZIP mice have
less hyperglycemia, lower circulating triglyceride and fatty acid levels, and lower mortality.
AZIP characteristics that are more severe on the B6 background include increased liver size …
on its genetic background. On both the FVB/N (FVB) and C57BL/6J (B6) backgrounds, AZIP
mice have a similarly severe lack of white adipose tissue and comparably increased insulin
levels and triglyceride secretion rates. However, on the B6 background, the AZIP mice have
less hyperglycemia, lower circulating triglyceride and fatty acid levels, and lower mortality.
AZIP characteristics that are more severe on the B6 background include increased liver size …