[HTML][HTML] Suppressors of cytokine signaling-1 and-6 associate with and inhibit the insulin receptor: a potential mechanism for cytokine-mediated insulin resistance
RA Mooney, J Senn, S Cameron, N Inamdar… - Journal of Biological …, 2001 - ASBMB
Insulin resistance contributes to a number of metabolic disorders, including type II diabetes,
hypertension, and atherosclerosis. Cytokines, such as tumor necrosis factor-α, interleukin-
1β, and interleukin-6, and hormones, such as growth hormone, are known to cause insulin
resistance, but the mechanisms by which they inhibit the cellular response to insulin have
not been elucidated. One mechanism by which these agents could cause insulin resistance
is by inducing the expression of cellular proteins that inhibit insulin receptor (IR) signaling …
hypertension, and atherosclerosis. Cytokines, such as tumor necrosis factor-α, interleukin-
1β, and interleukin-6, and hormones, such as growth hormone, are known to cause insulin
resistance, but the mechanisms by which they inhibit the cellular response to insulin have
not been elucidated. One mechanism by which these agents could cause insulin resistance
is by inducing the expression of cellular proteins that inhibit insulin receptor (IR) signaling …