[HTML][HTML] Neuritogenesis and the nerve growth factor-induced differentiation of PC-12 cells requires annexin II-mediated plasmin generation
AT Jacovina, F Zhong, E Khazanova, E Lev… - Journal of Biological …, 2001 - ASBMB
One of the key morphological changes associated with the nerve growth factor (NGF)-
induced differentiation of rat adrenal pheochromocytoma (PC-12) cells is the growth of axon-
like processes called neurites. A growing body of evidence suggests that this process may
be dependent upon plasmin, a serine protease generated from plasminogen (Plg) by either
urokinase Plg activator (u-PA) or tissue Plg activator (t-PA). Prior work in our laboratory has
identified annexin II (Ann-II) as a co-receptor for Plg and t-PA that promotes and localizes …
induced differentiation of rat adrenal pheochromocytoma (PC-12) cells is the growth of axon-
like processes called neurites. A growing body of evidence suggests that this process may
be dependent upon plasmin, a serine protease generated from plasminogen (Plg) by either
urokinase Plg activator (u-PA) or tissue Plg activator (t-PA). Prior work in our laboratory has
identified annexin II (Ann-II) as a co-receptor for Plg and t-PA that promotes and localizes …