Enhancement of glucuronide-conjugating capacity in a hyperbilirubinemic infant due to apparent enzyme induction by phenobarbital
SJ Yaffe, G Levy, T Matsuzawa… - New England Journal of …, 1966 - Mass Medical Soc
SJ Yaffe, G Levy, T Matsuzawa, T Baliah
New England Journal of Medicine, 1966•Mass Medical SocGLUCURONIDE conjugation is an important mechanism for the elimination of endogenous
and exogenous substances from the human body. 1 A defect in this mechanism leads to
increased concentrations of unconjugated bilirubin in the blood, and the latter is therefore
frequently a reflection of impaired glucuronide synthesis. 2 Patients with unusually low
capacity for the conjugation of bilirubin show a similar reduced capacity for glucuronide
conjugation of certain drugs that are ordinarily metabolized and eliminated by that process …
and exogenous substances from the human body. 1 A defect in this mechanism leads to
increased concentrations of unconjugated bilirubin in the blood, and the latter is therefore
frequently a reflection of impaired glucuronide synthesis. 2 Patients with unusually low
capacity for the conjugation of bilirubin show a similar reduced capacity for glucuronide
conjugation of certain drugs that are ordinarily metabolized and eliminated by that process …
GLUCURONIDE conjugation is an important mechanism for the elimination of endogenous and exogenous substances from the human body.1 A defect in this mechanism leads to increased concentrations of unconjugated bilirubin in the blood, and the latter is therefore frequently a reflection of impaired glucuronide synthesis.2 Patients with unusually low capacity for the conjugation of bilirubin show a similar reduced capacity for glucuronide conjugation of certain drugs that are ordinarily metabolized and eliminated by that process.3 , 4
Congenital, nonobstructive, nonhemolytic jaundice, which is thought to be due to a functional impairment of the glucuronyl transferase system, presents a particularly serious and difficult . . .
The New England Journal Of Medicine