Angiogenic and HIV-inhibitory functions of KSHV-encoded chemokines
C Boshoff, Y Endo, PD Collins, Y Takeuchi, JD Reeves… - Science, 1997 - science.org
C Boshoff, Y Endo, PD Collins, Y Takeuchi, JD Reeves, VL Schweickart, MA Siani, T Sasaki…
Science, 1997•science.orgUnique among known human herpesviruses, Kaposi's sarcoma–associated herpesvirus
(KSHV or HHV-8) encodes chemokine-like proteins (vMIP-I and vMIP-II). vMIP-II was shown
to block infection of human immunodeficiency virus–type 1 (HIV-1) on a CD4-positive cell
line expressing CCR3 and to a lesser extent on one expressing CCR5, whereas both vMIP-I
and vMIP-II partially inhibited HIV infection of peripheral blood mononuclear cells. Like
eotaxin, vMIP-II activated and chemoattracted human eosinophils by way of CCR3. vMIP-I …
(KSHV or HHV-8) encodes chemokine-like proteins (vMIP-I and vMIP-II). vMIP-II was shown
to block infection of human immunodeficiency virus–type 1 (HIV-1) on a CD4-positive cell
line expressing CCR3 and to a lesser extent on one expressing CCR5, whereas both vMIP-I
and vMIP-II partially inhibited HIV infection of peripheral blood mononuclear cells. Like
eotaxin, vMIP-II activated and chemoattracted human eosinophils by way of CCR3. vMIP-I …
Unique among known human herpesviruses, Kaposi's sarcoma–associated herpesvirus (KSHV or HHV-8) encodes chemokine-like proteins (vMIP-I and vMIP-II). vMIP-II was shown to block infection of human immunodeficiency virus–type 1 (HIV-1) on a CD4-positive cell line expressing CCR3 and to a lesser extent on one expressing CCR5, whereas both vMIP-I and vMIP-II partially inhibited HIV infection of peripheral blood mononuclear cells. Like eotaxin, vMIP-II activated and chemoattracted human eosinophils by way of CCR3. vMIP-I and vMIP-II, but not cellular MIP-1α or RANTES, were highly angiogenic in the chorioallantoic assay, suggesting a possible pathogenic role in Kaposi's sarcoma.
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