Rapid Communication: Absence of Human Herpesvirus 8 DNA Sequences in Neoplastic Kaposi's Sarcoma Cell Lines
L Flamand, RA Zeman, JL Bryant… - JAIDS Journal of …, 1996 - journals.lww.com
L Flamand, RA Zeman, JL Bryant, Y Lunardi-Iskandar, RC Gallo
JAIDS Journal of Acquired Immune Deficiency Syndromes, 1996•journals.lww.comThe recent detection of herpesvirus-like DNA sequences in Kaposi's sarcoma (KS) lesions
has led to numerous speculations regarding the role of this new agent in KS pathogenesis.
However, recent studies indicate a far wider distribution of such viral sequences, shadowing
the potential etiologic role of this agent in KS. In this report we show that malignant KS cell
lines do not harbor such viral sequences while B cells, CD14+ and CD34+ cells do,
suggesting that if a KS malignancy originates from infection with HHV-8, the virus can be lost …
has led to numerous speculations regarding the role of this new agent in KS pathogenesis.
However, recent studies indicate a far wider distribution of such viral sequences, shadowing
the potential etiologic role of this agent in KS. In this report we show that malignant KS cell
lines do not harbor such viral sequences while B cells, CD14+ and CD34+ cells do,
suggesting that if a KS malignancy originates from infection with HHV-8, the virus can be lost …
Abstract
The recent detection of herpesvirus-like DNA sequences in Kaposi's sarcoma (KS) lesions has led to numerous speculations regarding the role of this new agent in KS pathogenesis. However, recent studies indicate a far wider distribution of such viral sequences, shadowing the potential etiologic role of this agent in KS. In this report we show that malignant KS cell lines do not harbor such viral sequences while B cells, CD14+ and CD34+ cells do, suggesting that if a KS malignancy originates from infection with HHV-8, the virus can be lost and is not necessary for maintenance of the neoplastic state. Alternatively, HHV-8 may be a “passenger” in KS.
Lippincott Williams & Wilkins