[HTML][HTML] Insulin antiapoptotic signaling involves insulin activation of the nuclear factor κB-dependent survival genes encoding tumor necrosis factor receptor …
F Bertrand, C Desbois-Mouthon, A Cadoret… - Journal of Biological …, 1999 - ASBMB
We recently showed that the antiapoptotic function of insulin requires nuclear factor κB (NF-
κB) activation (Bertrand, F., Atfi, A., Cadoret, A., L'Allemain, G., Robin, H., Lascols, O.,
Capeau, J., and Cherqui, G.(1998) J. Biol. Chem. 273, 2931–2938). Here we sought to
identify the NF-κB-dependent survival genes that are activated by insulin to mediate this
function. Insulin increased the expression of tumor necrosis factor receptor-associated factor
2 (TRAF2) mRNA and protein in Chinese hamster ovary cells overexpressing insulin …
κB) activation (Bertrand, F., Atfi, A., Cadoret, A., L'Allemain, G., Robin, H., Lascols, O.,
Capeau, J., and Cherqui, G.(1998) J. Biol. Chem. 273, 2931–2938). Here we sought to
identify the NF-κB-dependent survival genes that are activated by insulin to mediate this
function. Insulin increased the expression of tumor necrosis factor receptor-associated factor
2 (TRAF2) mRNA and protein in Chinese hamster ovary cells overexpressing insulin …