[HTML][HTML] Muscle Protein Breakdown and the Critical Role of the Ubiquitin-Proteasome Pathway in Normal and Disease States12
SH Lecker, V Solomon, WE Mitch… - The Journal of …, 1999 - jn.nutrition.org
All intracellular proteins and many extracellular proteins are continually “turning over”; ie,
they are being hydrolyzed to their constituent amino acids and replaced by new synthesis.
This continual degradation of cell proteins was first discovered through the classic
experiments of Schoenheimer and coworkers in the 1940s using 15N-labeled amino acids
in adult animals (Schoenheimer 1942). However, after this surprising discovery, knowledge
about protein breakdown developed quite slowly. Since the late 1960s, there has been …
they are being hydrolyzed to their constituent amino acids and replaced by new synthesis.
This continual degradation of cell proteins was first discovered through the classic
experiments of Schoenheimer and coworkers in the 1940s using 15N-labeled amino acids
in adult animals (Schoenheimer 1942). However, after this surprising discovery, knowledge
about protein breakdown developed quite slowly. Since the late 1960s, there has been …