Defective repair of oxidative damage in mitochondrial DNA in Down's syndrome
N Druzhyna, RG Nair, SP LeDoux, GL Wilson - Mutation Research/DNA …, 1998 - Elsevier
Recent evidence indicates that oxidative DNA damage may be a major cause of aging. One
of the more sensitive targets is the mitochondrial genome which is 10 times more
susceptible to mutation than is the nuclear genome. A number of age-related neuromuscular
degenerative diseases also have been associated with mutations in mitochondrial DNA
(mtDNA), and progressive accumulation of oxidative damage in mtDNA from neuronal
tissues over time has been shown. In support of the notion that oxidative stress leads to …
of the more sensitive targets is the mitochondrial genome which is 10 times more
susceptible to mutation than is the nuclear genome. A number of age-related neuromuscular
degenerative diseases also have been associated with mutations in mitochondrial DNA
(mtDNA), and progressive accumulation of oxidative damage in mtDNA from neuronal
tissues over time has been shown. In support of the notion that oxidative stress leads to …