[PDF][PDF] Thinking beyond the tumor cell: Nf1 haploinsufficiency in the tumor environment
ME McLaughlin, T Jacks - Cancer cell, 2002 - cell.com
ME McLaughlin, T Jacks
Cancer cell, 2002•cell.comThinking beyond the tumor cell: Nf1 haploinsufficiency in the tumor environment Page 1 408
CANCER CELL : JUNE 2002 PREVIEWS death of the affected cell. More generally, there is
now a fertile and sometimes fractious dispute as to the importance of genome instability in
tumorigenesis. On the one extreme, some have argued aneuploidy is the fundamental
mechanism of tumorigenesis, with activated oncogenes and wrecked tumor suppressors
merely a sideshow to distract gullible molecular biologists (Duesberg, 1999). More mainstream …
CANCER CELL : JUNE 2002 PREVIEWS death of the affected cell. More generally, there is
now a fertile and sometimes fractious dispute as to the importance of genome instability in
tumorigenesis. On the one extreme, some have argued aneuploidy is the fundamental
mechanism of tumorigenesis, with activated oncogenes and wrecked tumor suppressors
merely a sideshow to distract gullible molecular biologists (Duesberg, 1999). More mainstream …
Abstract
Deletion of both copies of the Nf1 gene in Schwann cells combined with Nf1 heterozygosity in the tumor environment promotes neurofibroma formation in mice.
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