[HTML][HTML] Neurofibromin GTPase-activating protein-related domains restore normal growth in Nf1−/− cells
KK Hiatt, DA Ingram, Y Zhang, G Bollag… - Journal of Biological …, 2001 - ASBMB
Members of the Ras superfamily of signaling proteins modulate fundamental cellular
processes by cycling between an active GTP-bound conformation and an inactive GDP-
bound form. Neurofibromin, the protein product of the NF1 tumor suppressor gene, and
p120GAP are GTPase-activating proteins (GAPs) for p21 Ras (Ras) and negatively regulate
output by accelerating GTP hydrolysis on Ras. Neurofibromin and p120GAP differ markedly
outside of their conserved GAP-related domains (GRDs), and it is therefore unknown if the …
processes by cycling between an active GTP-bound conformation and an inactive GDP-
bound form. Neurofibromin, the protein product of the NF1 tumor suppressor gene, and
p120GAP are GTPase-activating proteins (GAPs) for p21 Ras (Ras) and negatively regulate
output by accelerating GTP hydrolysis on Ras. Neurofibromin and p120GAP differ markedly
outside of their conserved GAP-related domains (GRDs), and it is therefore unknown if the …