[HTML][HTML] Apg14p and Apg6/Vps30p form a protein complex essential for autophagy in the yeast, Saccharomyces cerevisiae
S Kametaka, T Okano, M Ohsumi, Y Ohsumi - Journal of Biological …, 1998 - ASBMB
Mutation in the Saccharomyces cerevisiae APG14 gene causes a defect in autophagy.
Cloning and structural analysis of the APG14 gene revealed that APG14 encodes a novel
hydrophilic protein with a predicted molecular mass of 40.5 kDa, and that Apg14p has a
coiled-coil motif at its N terminus region. We found that overproduction of Apg14p partially
reversed the defect in autophagy induced by theapg6-1 mutation. The apg6-1 mutant was
found to be defective not only in autophagy but also in sorting of carboxypeptidase Y (CPY) …
Cloning and structural analysis of the APG14 gene revealed that APG14 encodes a novel
hydrophilic protein with a predicted molecular mass of 40.5 kDa, and that Apg14p has a
coiled-coil motif at its N terminus region. We found that overproduction of Apg14p partially
reversed the defect in autophagy induced by theapg6-1 mutation. The apg6-1 mutant was
found to be defective not only in autophagy but also in sorting of carboxypeptidase Y (CPY) …