[HTML][HTML] Thiazolidinediones block fatty acid release by inducing glyceroneogenesis in fat cells
J Tordjman, G Chauvet, J Quette, EG Beale… - Journal of Biological …, 2003 - ASBMB
Thiazolidinediones are used to treat type 2 diabetes mellitus because they decrease plasma
glucose, insulin, triglyceride, and fatty acid levels. Thiazolidinediones are agonists for
peroxisome proliferator-activated receptor γ, a nuclear receptor that is highly expressed in
fat tissue. We identify glyceroneogenesis as a target of thiazolidinediones in cultured
adipocytes and fat tissues of Wistar rats. The activation of glyceroneogenesis by
thiazolidinediones occurs mainly in visceral fat, the same fat depot that is specifically …
glucose, insulin, triglyceride, and fatty acid levels. Thiazolidinediones are agonists for
peroxisome proliferator-activated receptor γ, a nuclear receptor that is highly expressed in
fat tissue. We identify glyceroneogenesis as a target of thiazolidinediones in cultured
adipocytes and fat tissues of Wistar rats. The activation of glyceroneogenesis by
thiazolidinediones occurs mainly in visceral fat, the same fat depot that is specifically …