[HTML][HTML] Cholesterol, a cell size-dependent signal that regulates glucose metabolism and gene expression in adipocytes* 210
Enlarged fat cells exhibit modified metabolic capacities, which could be involved in the
metabolic complications of obesity at the whole body level. We show here that sterol
regulatory element-binding protein 2 (SREBP-2) and its target genes are induced in the
adipose tissue of several models of rodent obesity, suggesting cholesterol imbalance in
enlarged adipocytes. Within a particular fat pad, larger adipocytes have reduced membrane
cholesterol concentrations compared with smaller fat cells, demonstrating that altered …
metabolic complications of obesity at the whole body level. We show here that sterol
regulatory element-binding protein 2 (SREBP-2) and its target genes are induced in the
adipose tissue of several models of rodent obesity, suggesting cholesterol imbalance in
enlarged adipocytes. Within a particular fat pad, larger adipocytes have reduced membrane
cholesterol concentrations compared with smaller fat cells, demonstrating that altered …