Effect of leptin on arterial thrombosis following vascular injury in mice
PF Bodary, RJ Westrick, KJ Wickenheiser, Y Shen… - Jama, 2002 - jamanetwork.com
ContextComplications of atherosclerosis are the leading cause of morbidity and mortality in
industrialized societies. Obesity has emerged as an independent risk factor for
complications of atherosclerotic vascular disease. Leptin, a hormone produced by the
adipocyte, increases with obesity and appears to modulate energy balance and food intake.
In addition, other actions of leptin have been proposed, including an in vitro effect on platelet
aggregation. Thus, the elevated plasma leptin levels in obese individuals may promote …
industrialized societies. Obesity has emerged as an independent risk factor for
complications of atherosclerotic vascular disease. Leptin, a hormone produced by the
adipocyte, increases with obesity and appears to modulate energy balance and food intake.
In addition, other actions of leptin have been proposed, including an in vitro effect on platelet
aggregation. Thus, the elevated plasma leptin levels in obese individuals may promote …