Semiquantitative aspects of mast cells in normal skin and in neurofibromas of neurofibromatosis types 1 and 5
M Nürnberger, I Moll - Dermatology, 1994 - karger.com
M Nürnberger, I Moll
Dermatology, 1994•karger.comMast cells are supposed to influence the growth of neurofibromas, because some of their
mediators may also act as growth factors. Accordingly, mast cell stabilizers are claimed to
reduce proliferation and itching of neurofibromas. Therefore, we quantified the mast cells of
19 neurofibromas and compared them with normal skin. We saw a statistically significant
increase in mast cells in neurofibromas versus normal skin. However, there is no correlation
between the age of neurofibromatosis (NF) patients and mast cell density. In our study the …
mediators may also act as growth factors. Accordingly, mast cell stabilizers are claimed to
reduce proliferation and itching of neurofibromas. Therefore, we quantified the mast cells of
19 neurofibromas and compared them with normal skin. We saw a statistically significant
increase in mast cells in neurofibromas versus normal skin. However, there is no correlation
between the age of neurofibromatosis (NF) patients and mast cell density. In our study the …
Abstract
Mast cells are supposed to influence the growth of neurofibromas, because some of their mediators may also act as growth factors. Accordingly, mast cell stabilizers are claimed to reduce proliferation and itching of neurofibromas. Therefore, we quantified the mast cells of 19 neurofibromas and compared them with normal skin. We saw a statistically significant increase in mast cells in neurofibromas versus normal skin. However, there is no correlation between the age of neurofibromatosis (NF) patients and mast cell density. In our study the density of mast cells in neurofibromas is also independent of NF type, age of neurofibroma and chronic ultraviolet exposure in contrast to normal skin. Different tumors of the same patient had similar mast cell counts.
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