[HTML][HTML] Tissue-specific ablation of the GLUT4 glucose transporter or the insulin receptor challenges assumptions about insulin action and glucose homeostasis
Y Minokoshi, CR Kahn, BB Kahn - Journal of Biological Chemistry, 2003 - ASBMB
The prevalence of type 2 diabetes mellitus is growing worldwide. Most forms of type 2
diabetes are polygenic with complex inheritance patterns strongly influenced by
environmental factors. The specific gene defects are unknown, but they affect both insulin
action and insulin secretion. Glucose homeostasis is maintained by the fine orchestration of
insulin secretion and insulin action to promote glucose transport into muscle and adipocytes
and to inhibit hepatic glucose output. Resistance to these effects of insulin is a classic …
diabetes are polygenic with complex inheritance patterns strongly influenced by
environmental factors. The specific gene defects are unknown, but they affect both insulin
action and insulin secretion. Glucose homeostasis is maintained by the fine orchestration of
insulin secretion and insulin action to promote glucose transport into muscle and adipocytes
and to inhibit hepatic glucose output. Resistance to these effects of insulin is a classic …