CD8+CD28− T suppressor cells and the induction of antigen‐specific, antigen‐presenting cell‐mediated suppression of Th reactivity
R Cortesini, J LeMaoult, R Ciubotariu… - Immunological …, 2001 - Wiley Online Library
R Cortesini, J LeMaoult, R Ciubotariu, NSF Cortesini
Immunological reviews, 2001•Wiley Online LibraryHuman CD8+ CD28− suppressor T cells (Ts) are a subset of T cells generated in the course
of in vitro and in vivo immunizations. Ts recognize MHC class I: peptide complexes and
inhibit the reactivity of T helper cells (Th) with cognate antigen specificity. We have
demonstrated for the first time that CD8+ CD28− Ts represent a unique subset of regulatory
cells that induces the differentiation of tolerogenic antigen‐presenting cells, initiating a
suppressive loop which results in the induction and spreading of Th unresponsiveness.
of in vitro and in vivo immunizations. Ts recognize MHC class I: peptide complexes and
inhibit the reactivity of T helper cells (Th) with cognate antigen specificity. We have
demonstrated for the first time that CD8+ CD28− Ts represent a unique subset of regulatory
cells that induces the differentiation of tolerogenic antigen‐presenting cells, initiating a
suppressive loop which results in the induction and spreading of Th unresponsiveness.
Summary
Human CD8+CD28− suppressor T cells (Ts) are a subset of T cells generated in the course of in vitro and in vivo immunizations. Ts recognize MHC class I:peptide complexes and inhibit the reactivity of T helper cells (Th) with cognate antigen specificity. We have demonstrated for the first time that CD8+CD28− Ts represent a unique subset of regulatory cells that induces the differentiation of tolerogenic antigen‐presenting cells, initiating a suppressive loop which results in the induction and spreading of Th unresponsiveness.
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