[HTML][HTML] HOXB4 overexpression mediates very rapid stem cell regeneration and competitive hematopoietic repopulation
J Antonchuk, G Sauvageau, RK Humphries - Experimental hematology, 2001 - Elsevier
OBJECTIVE: Hox transcription factors have emerged as important regulators of
hematopoiesis. In particular, we have shown that overexpression of HOXB4 in mouse bone
marrow can greatly enhance the level of hematopoietic stem cell (HSC) regeneration
achieved at late times (> 4 months) posttransplantation. The objective of this study was to
resolve if HOXB4 increases the rate and/or duration of HSC regeneration, and also to see if
this enhancement was associated with impaired production of end cells or would lead to …
hematopoiesis. In particular, we have shown that overexpression of HOXB4 in mouse bone
marrow can greatly enhance the level of hematopoietic stem cell (HSC) regeneration
achieved at late times (> 4 months) posttransplantation. The objective of this study was to
resolve if HOXB4 increases the rate and/or duration of HSC regeneration, and also to see if
this enhancement was associated with impaired production of end cells or would lead to …