Single base deletion in the vasopressin gene is the cause of diabetes insipidus in Brattleboro rats
H Schmale, D Richter - Nature, 1984 - nature.com
H Schmale, D Richter
Nature, 1984•nature.comIn rats with hereditary hypothalamic diabetes insipidus (Brattleboro rats) the gene for the
vasopressin precursor lacks a single G residue in the protein-coding region. The mutation
gives rise to an open reading frame predicting a hormone precursor having a different C-
terminus.
vasopressin precursor lacks a single G residue in the protein-coding region. The mutation
gives rise to an open reading frame predicting a hormone precursor having a different C-
terminus.
Abstract
In rats with hereditary hypothalamic diabetes insipidus (Brattleboro rats) the gene for the vasopressin precursor lacks a single G residue in the protein-coding region. The mutation gives rise to an open reading frame predicting a hormone precursor having a different C-terminus.
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