Neutrophil- and Glutathione-Mediated Hepatotoxicity of α-Naphthylisothiocyanate

RA Roth, LJ Dahm - Drug Metabolism Reviews, 1997 - Taylor & Francis
RA Roth, LJ Dahm
Drug Metabolism Reviews, 1997Taylor & Francis
This presentation focuses on mechanisms of a-naphthylisothiocyanate (ANIT)-induced
toxicity. It is particularly fitting that a discussion of the hepatotoxicity of ANIT should be
included in a monograph honoring Dr. Gabriel Plaa since it was he and his students who
provided us with the characterization of ANIT hepatotoxicity and initial explorations into the
mechanisms by which it works. Indeed, Dr. Plaa's contributions formed the basis for much of
our explorations of ANIT hepatotoxicity that are presented in this short review. This …
This presentation focuses on mechanisms of a-naphthylisothiocyanate (ANIT)-induced toxicity. It is particularly fitting that a discussion of the hepatotoxicity of ANIT should be included in a monograph honoring Dr. Gabriel Plaa since it was he and his students who provided us with the characterization of ANIT hepatotoxicity and initial explorations into the mechanisms by which it works. Indeed, Dr. Plaa’s contributions formed the basis for much of our explorations of ANIT hepatotoxicity that are presented in this short review. This discussion comprises a brief summary primarily of the hepatotoxic effects of ANIT and a synopsis of our explorations into the neutrophil dependency of ANIT hepatotoxicity and into the role of glutathione in the transport of ANIT within the liver.
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