Role of MRP2 and GSH in intrahepatic cycling of toxins
CG Dietrich, R Ottenhoff, DR de Waart, RPJO Elferink - Toxicology, 2001 - Elsevier
MRP2 is a canalicular transporter in hepatocytes mediating the transport of a wide spectrum
of amphipathic compounds. This includes organic anions but also compounds complexed
with GSH as, eg α-naphthylisothiocyanate (ANIT) and arsenite. These reversible complexes
may fall apart in bile after MRP2-mediated transport, which induces high concentrations of
the toxic compound in the biliary tree. To further investigate the role of MRP2 in transport
and toxicity of both compounds, we conducted experiments in transduced polarized …
of amphipathic compounds. This includes organic anions but also compounds complexed
with GSH as, eg α-naphthylisothiocyanate (ANIT) and arsenite. These reversible complexes
may fall apart in bile after MRP2-mediated transport, which induces high concentrations of
the toxic compound in the biliary tree. To further investigate the role of MRP2 in transport
and toxicity of both compounds, we conducted experiments in transduced polarized …