[HTML][HTML] Bile acids stimulate cFLIP phosphorylation enhancing TRAIL-mediated apoptosis
H Higuchi, JH Yoon, A Grambihler, N Werneburg… - Journal of Biological …, 2003 - ASBMB
Bile acids induce hepatocyte injury by enhancing death receptor-mediated apoptosis. In this
study, bile acid effects on TRAIL-mediated apoptosis were examined to gain insight into bile
acid potentiation of death receptor signaling. TRAIL-induced apoptosis of HuH-7 cells, stably
transfected with a bile acid transporter, was enhanced by bile acids. Caspase 8 and 10
activation, bid cleavage, cytosolic cytochrome c, and caspase 3 activation by TRAIL were all
increased by the bile acid glycochenodeoxycholate (GCDCA). GCDCA (100 μm) did not …
study, bile acid effects on TRAIL-mediated apoptosis were examined to gain insight into bile
acid potentiation of death receptor signaling. TRAIL-induced apoptosis of HuH-7 cells, stably
transfected with a bile acid transporter, was enhanced by bile acids. Caspase 8 and 10
activation, bid cleavage, cytosolic cytochrome c, and caspase 3 activation by TRAIL were all
increased by the bile acid glycochenodeoxycholate (GCDCA). GCDCA (100 μm) did not …