Cellular localization and up-regulation of multidrug resistance–associated protein 3 in hepatocytes and cholangiocytes during obstructive cholestasis in rat liver
CJ Soroka, JM Lee, F Azzaroli, JL Boyer - Hepatology, 2001 - Elsevier
The hepatic expression of the ATP-dependent conjugate export pump multidrug resistance–
associated protein 2 (Mrp2) is diminished in experimentally induced models of cholestasis.
In this study we have examined the localization and expression of Mrp3, another member of
the multidrug resistance–associated protein family, in normal liver and after obstructive
cholestasis in the rat. Indirect immunofluorescence and confocal microscopy were used to
determine the tissue localization and Western blot analysis was performed to quantitate the …
associated protein 2 (Mrp2) is diminished in experimentally induced models of cholestasis.
In this study we have examined the localization and expression of Mrp3, another member of
the multidrug resistance–associated protein family, in normal liver and after obstructive
cholestasis in the rat. Indirect immunofluorescence and confocal microscopy were used to
determine the tissue localization and Western blot analysis was performed to quantitate the …