S-adenosyl-l-methionine protection against α-naphthyl-isothiocyanate-induced cholestasis in the rat
C Di Padovaa, F Di Padova, R Tritapepe… - Toxicology letters, 1985 - Elsevier
The effect of S-adenosyl-l-methionine (SAMe) on cholestasis induced by α-
naphthylisothiocyanate (ANIT) was studied in rats. SAMe significantly attenuated both bile
flow impairment and elevated values of serum bilirubin, glutamic pyruvic transaminase and
alkaline phosphatase in ANIT-treated animals. These results suggest that SAMe protects the
rat liver against the toxic effects of ANIT.
naphthylisothiocyanate (ANIT) was studied in rats. SAMe significantly attenuated both bile
flow impairment and elevated values of serum bilirubin, glutamic pyruvic transaminase and
alkaline phosphatase in ANIT-treated animals. These results suggest that SAMe protects the
rat liver against the toxic effects of ANIT.