Immunoglobulin G fractions from patients with antiphospholipid antibodies cause fetal death in BALB/c mice: a model for autoimmune fetal loss
DW Branch, DJ Dudley, MD Mitchell… - American journal of …, 1990 - Elsevier
We determined whether purified immunoglobulin G from patients with antiphospholipid
antibodies causes fetal loss in pregnant mice. Sera were obtained from nonpregnant parous
women (group 1) and nonpregnant women with antiphospholipid antibodies and a history of
fetal loss (group 2). Pregnant BALB/c mice were given an intraperitoneal injection of 15 mg
of IgG on day 8 of pregnancy. Typically, mice treated with IgG from anti phospholipid
antibodies aborted within 48 hours. When animals were sacrificed on days 9 to 15, the …
antibodies causes fetal loss in pregnant mice. Sera were obtained from nonpregnant parous
women (group 1) and nonpregnant women with antiphospholipid antibodies and a history of
fetal loss (group 2). Pregnant BALB/c mice were given an intraperitoneal injection of 15 mg
of IgG on day 8 of pregnancy. Typically, mice treated with IgG from anti phospholipid
antibodies aborted within 48 hours. When animals were sacrificed on days 9 to 15, the …