Cytogenetics of the chronic myeloid leukemia-derived cell line K562: karyotype clarification by multicolor fluorescence in situ hybridization, comparative genomic …
SM Gribble, I Roberts, C Grace, KM Andrews… - Cancer genetics and …, 2000 - Elsevier
The transformation of chronic myeloid leukemia (CML) from a chronic phase to an acute
phase is frequently accompanied by additional chromosome changes. Extensive
chromosome G-banded studies have revealed the secondary changes are nonrandom and
frequently include trisomy 8, isochromosome 17q, trisomy 19, or an extra copy of the
Philadelphia chromosome. In addition to these secondary chromosome changes, complex
structural rearrangements often occur to form marker structures that remain unidentified by …
phase is frequently accompanied by additional chromosome changes. Extensive
chromosome G-banded studies have revealed the secondary changes are nonrandom and
frequently include trisomy 8, isochromosome 17q, trisomy 19, or an extra copy of the
Philadelphia chromosome. In addition to these secondary chromosome changes, complex
structural rearrangements often occur to form marker structures that remain unidentified by …
